{"id":1142,"date":"2011-02-15T11:08:15","date_gmt":"2011-02-15T09:08:15","guid":{"rendered":"http:\/\/oldblogs.uct.ac.za\/blog\/big-bytes\/2011\/02\/15\/visualization-of-hemorrhagic-viruses"},"modified":"2022-09-26T20:06:28","modified_gmt":"2022-09-26T18:06:28","slug":"visualization-of-hemorrhagic-viruses","status":"publish","type":"post","link":"https:\/\/ucthpc.uct.ac.za\/index.php\/2011\/02\/15\/visualization-of-hemorrhagic-viruses\/","title":{"rendered":"Visualization of Hemorrhagic Viruses"},"content":{"rendered":"\"Hanta\r\n\r\n\"The hanta viruses are emerging infectious viruses that in humans can cause a cardiopulmonary syndrome or a hemorrhagic fever with renal syndrome. The nucleocapsid (N) is the most abundant viral protein, and during viral assembly, the N protein forms trimers and packages the viral RNA genome.\u00a0 N1-74 forms two long helices (alpha1 and alpha2) that intertwine into a coiled coil domain. The conserved hydrophobic residues at the helix alpha1-alpha2 interface stabilize the coiled coil; however, there are many conserved surface residues whose function is not known<\/em>\"\r\n\r\nExtracts from a citation by: Wang, Y.,\u00a0\u00a0 Boudreaux, D.M.,\u00a0\u00a0 Estrada, D.F.,\u00a0\u00a0 Egan, C.W.,\u00a0\u00a0 St Jeor, S.C.,\u00a0\u00a0 De Guzman, R.N.\r\n\r\nDownloaded from the Protein Data Bank<\/a>, and visualized with VMD<\/a>.\r\n\r\nWhy is this so important?<\/strong>\u00a0 The Lujo<\/a> virus, a newly identified viral heamorrhagic fever, was recently identified in South Africa after a fatal outbreak of the disease in Johannesburg.\u00a0 Use of tools such as NAMD and VMD can assist scientists in understanding the behaviour of these organisms and hopefuly determine methods to combat them.","protected":false},"excerpt":{"rendered":"

\"Hanta<\/p>\n

“The hanta viruses are emerging infectious viruses that in humans can cause a cardiopulmonary syndrome or a hemorrhagic fever with renal syndrome. The nucleocapsid (N) is the most abundant viral protein, and during viral assembly, the N protein forms trimers and packages the viral RNA genome.  N1-74 forms two long helices (alpha1 and alpha2) that intertwine into a coiled coil domain. The conserved hydrophobic residues at the helix alpha1-alpha2 interface stabilize the coiled coil; however, there are many conserved surface residues whose function is not known<\/em>” <\/span><\/p>\n

Extracts from a citation by: Wang, Y.,   Boudreaux, D.M.,   Estrada, D.F.,   Egan, C.W.,   St Jeor, S.C.,   De Guzman, R.N. <\/p>\n

Downloaded from the Protein Data Bank<\/a>, and visualized with VMD<\/a>.<\/p>\n

Why is this so important?<\/strong>  The Lujo<\/a> virus, a newly identified viral heamorrhagic fever, was recently identified in South Africa after a fatal outbreak of the disease in Johannesburg.  Use of tools such as NAMD and VMD can assist scientists in understanding the behaviour of these organisms and hopefuly determine methods to combat them.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[9],"tags":[],"yoast_head":"\nVisualization of Hemorrhagic Viruses - UCT HPC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ucthpc.uct.ac.za\/index.php\/2011\/02\/15\/visualization-of-hemorrhagic-viruses\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Visualization of Hemorrhagic Viruses - UCT HPC\" \/>\n<meta property=\"og:description\" content=\""The hanta viruses are emerging infectious viruses that in humans can cause a cardiopulmonary syndrome or a hemorrhagic fever with renal syndrome. The nucleocapsid (N) is the most abundant viral protein, and during viral assembly, the N protein forms trimers and packages the viral RNA genome.  N1-74 forms two long helices (alpha1 and alpha2) that intertwine into a coiled coil domain. The conserved hydrophobic residues at the helix alpha1-alpha2 interface stabilize the coiled coil; however, there are many conserved surface residues whose function is not known" Extracts from a citation by: Wang, Y.,   Boudreaux, D.M.,   Estrada, D.F.,   Egan, C.W.,   St Jeor, S.C.,   De Guzman, R.N. Downloaded from the Protein Data Bank, and visualized with VMD.Why is this so important?  The Lujo virus, a newly identified viral heamorrhagic fever, was recently identified in South Africa after a fatal outbreak of the disease in Johannesburg.  Use of tools such as NAMD and VMD can assist scientists in understanding the behaviour of these organisms and hopefuly determine methods to combat them.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ucthpc.uct.ac.za\/index.php\/2011\/02\/15\/visualization-of-hemorrhagic-viruses\/\" \/>\n<meta property=\"og:site_name\" content=\"UCT HPC\" \/>\n<meta property=\"article:published_time\" content=\"2011-02-15T09:08:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-09-26T18:06:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ucthpc.uct.ac.za\/wp-content\/uploads\/2015\/07\/HantaVirus.png\" \/>\n<meta name=\"author\" content=\"Andrew Lewis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Andrew Lewis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ucthpc.uct.ac.za\/index.php\/2011\/02\/15\/visualization-of-hemorrhagic-viruses\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ucthpc.uct.ac.za\/index.php\/2011\/02\/15\/visualization-of-hemorrhagic-viruses\/\"},\"author\":{\"name\":\"Andrew Lewis\",\"@id\":\"https:\/\/ucthpc.uct.ac.za\/#\/schema\/person\/c183ad1c0a1063124a72d63963ae9c7e\"},\"headline\":\"Visualization of Hemorrhagic Viruses\",\"datePublished\":\"2011-02-15T09:08:15+00:00\",\"dateModified\":\"2022-09-26T18:06:28+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ucthpc.uct.ac.za\/index.php\/2011\/02\/15\/visualization-of-hemorrhagic-viruses\/\"},\"wordCount\":180,\"publisher\":{\"@id\":\"https:\/\/ucthpc.uct.ac.za\/#organization\"},\"articleSection\":[\"application\"],\"inLanguage\":\"en-ZA\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ucthpc.uct.ac.za\/index.php\/2011\/02\/15\/visualization-of-hemorrhagic-viruses\/\",\"url\":\"https:\/\/ucthpc.uct.ac.za\/index.php\/2011\/02\/15\/visualization-of-hemorrhagic-viruses\/\",\"name\":\"Visualization of Hemorrhagic Viruses - 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